|
KMID : 0379520020180010023
|
|
한국독성학회지
2002 Volume.18 No. 1 p.23 ~ p.29
|
|
|
Initial Risk Assessment of Disodium Disulphite in OECD High Production Volume Chemical Program
|
|
Song Sang-Hwan
Park Yoon-Ho
Park Hye-Youn
Kwon Min-Jeoung
Koo Hyun-Ju
Jeon Seong-Hwan
Na Jin-Gyun
Park Kwang-Sik
|
|
|
Abstract
|
|
|
|
Disodium disulphite, the HPV chemical, was assigned to Korea in order to implement OECD SIDS program in 1999. It was produced about 3,200 ton/year in 1998. This report evaluates the toxic potency of disodium disulphite based on the environmental and mammalian effects as well as human exposure. Oral LD_{50} in rats is 1,540 mg/kg b.w. and effects was observed to the stomach, liver and the GI track that was filled with blood. For repeated dose toxicity, the predominant effect was the induction of stomach lesion due to local irritation. The no observed adverse effect lever for local (stomach irritation) was about 217 mg/kg bw/day. There is no evidence that disodium disulphite is genotoxic in vivo. No reproductive or developmental toxicty of disodium disulphite was observed for the period up to 2 yr and over three generation. In humans, urticaria and asthma with itching, edema, rhinitis, and nasal congestion were reported. Disodium disulphite is unlikely to induce respiratory sensitization but may enhance symptom of asthma in sensitive individuals. This chemical would be mainly transported to water compartment when released to environmental compartments since it is highly water soluble (470 g/l at 20). Low K oc (2.447) indicates disodium disulphite is so mobile in soil that it may not stay in the terrestrial compartment. The chemical has been tested in a limited number of aquatic species. hem acute toxicity test to fish, 96 hr-LC_{50} was > 100 mg/1. For algae, 72 hr-XC_{50} was 48.1 mg/1. For daphnid, the acute toxicity value of 48 hr-EC_{50} was 88.76 mg/1, and chronic value of 21day-NOEC was > 10 mg/1. Therefore, PNEC of 0.1 mg/l for the aquatic organism was obtained from the chronic value of daphnid using the assessment factor of 100. Based on these data the disodium disulphite was recommended as low priority for further post-SIDS work in OECD.
|
|
|
KEYWORD
|
|
|
Disodium disulphite, Hazard assessment, SIDS (screening Information Data Set), SIAM(SIDS initial Assessment Meeting)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|